Aminoguanidine Hydrochloride
Igama lemveliso:I-carbazamidine hydrochloride; (diaminomethylidene) hydrazinium chloride
Ifomula yeMolekyuli:CH6N4HCL
CAS:Ngo-1937-19-5
Ubunzima Ezinto:110.55
Ifomula yolwakhiwo:
Sebenzisa:Amayeza, amayeza emfuyo
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Isalathiso igama |
Ixabiso le-Index |
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Inkangeleko |
Mhlophe njenge powder crystalline |
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Umxholo |
≥Iipesenti ezingama-98 |
≥99% |
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Izinto ezingenakunyibilika |
≤0.2% |
≤0.1% |
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Ilahleko ekomiseni |
≤1.5% |
≤1% |
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Ucinezelo Intsalela |
≤0.2% |
≤0.1% |
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Umxholo wentsimbi (Fe) |
10 ppm |
6 ipm |
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Acid Simahla |
≤0.8% |
≤0.5% |
amalungiselelo
Ukulungiswa kwe-aminoguanidine hydrochloride: i-9 g ye-aminoguanidine carbonate yafakwa kwi-250ml ezintathu kwizibuko, i-20ml ye-ethanol epheleleyo yongezwa, okuqinileyo kwakunganyibiliki kwi-anhydrous ethanol ukwenza ukumiswa. Phantsi kovuselelo kubushushu begumbi, umxube we-6ml 30% egxile kwi-hydrochloric acid kunye ne-10ml ye-ethanol epheleleyo yongezwa nge-dropwise kwade kwakungekho bubble, emva koko kwavuselelwa impendulo kwaqhubeka kubushushu begumbi iyure enye. Ukumiswa okufumanisiweyo kwafudumeza ukunyibilikisa okuqinileyo, emva koko kwehliswa ngokwemvelo kubushushu begumbi. Emva kokuhanjiswa kwifriji kwaye ibekwe ubusuku bonke, ikristale emhlophe emise intonga enendawo yokunyibilika ye-166-167℃ yafunyanwa.
Ukusetyenziswa
I-Daidzein ineempembelelo ezahlukeneyo ze-pharmacological, ukuthintela kunye nokunyanga izifo ezahlukeneyo I-Cn200910144204.1 ixele ukuba i-aminoguanidine hydrochloride inokusetyenziselwa ukulungisa i-daidzein eguqulweyo ngemichiza, eyile, daidzein 7,4 '- oxy aminoguanidine acetate. Isoya aglycone 7,4 '- oxy aminoguanidine acetate sisixhobo seprodrug, esikhupha ichiza elingumzali - i-daidzein phantsi kweemeko zomzimba, kwaye iphucula ukunyibilika kwamanzi ngokubopha ngokudibeneyo.
Ukulungiswa kukaDaidzein 7,4 ' - o-aminoguanidine acetate: I-0.5g ye-aminoguanidine hydrochloride yachithwa kwi-100ml acetone, i-0.02g yesigaba sokudlulisa i-catalyst, i-0.5g i-potassium carbonate, i-0.5g 7,4 ' I-chloroacetyl daidzein kunye ne-0.02g I2 zongezwa kwisisombululo Impendulo yenziwa kubushushu begumbi iiyure ezingama-24. I-Acetone yenziwa ngumphunga ukusuka kwifilitha phantsi koxinzelelo oluncitshisiweyo, emva koko yahlulwa yikholamu yesilica yejeli. I-eluent yayiyi-acetate ye-ethyl∶ I-petroleum ether Xa umlinganiselo uyi-1 ∶ 2, umgubo omhlophe oqinileyo ufumaneka.